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pentobarbital will lessen the extent or effect of ritonavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will lower the level or impact of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Potent CYP3A4 inducers are predicted to result in